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Basic Organic Chemistry-I

CSO 201


3-1-0 [11]


Courses with significant overlap with this course:

Semester of last offering:

Date of approval: dd-mmm-yyyy

Prerequisites: CHM102,Remarks: Same as CHM 203Objectives of the courseThis is the first course in Aerodynamics. The course deals with incompressible flows past airfoil sections and wings. Topics 

Nomenclature of Organic molecules:(1)

  • Brief revision, Nomenclature of polycyclic compounds including bridged, spiro and other special structures.

Structure and Bonding: (2)

  • Nature of bonding in aliphatic, alicyclic, aromatic and heterocyclic compounds; Aromaticity in benzenoid and non-benzenoid compounds. Alternant and non-alternant hydrocarbons; Dipole moment; Resonance; Inductive and Field effects, hyperconjugation, Steric inhibition of resonance, structural effects on acidity and basicity.

Stereochemistry: (10)

  • Conformational analysis of acyclic systems (Pitzer strain, A strain, etc.) and cyclohexane systems (brief review as studied in Chm 201). Introduction of terminologies such as erythro, threo, r, r, exo, endo, epimers, etc. Conformational analysis of decalins and other polycyclic compounds related to

  • A brief introduction to asymmetric synthesis; Induction of chirality on a prochiral carbon atom; R and S nomenclature in

    (i) cyclic systems
    (ii) in compounds with more than one chiral centre and
    (iii) in biphenyls, allenes and spiro compounds. Optical isomerism in compounds without an asymmetric atom, Racemic modifications.

  • Conformation of acyclic molecules, topicity and prostereoisomerism (topicity of ligands and faces), chemical and biochemical transformations of heterotopic ligands and faces. Conformations of cyclic, fused and bridged ring compounds. Allylic strain (A1,2 and A1,3) and other strains.

Reactive Intermediates: (8)

  • Carbocations; carbanions; free radicals, radical anions and cations; arynes; carbenes and nitrenes
    (Introduction to structure, stability, and reactions).

Substitution and Elimination Reactions (9)

  • Electrophilic aromatic substitution (in detail); Aliphatic substitutions: SN1, SN2, SN2′ and SNi reactions; neighbouring group participation. Nucleophilic aromatic substitution (brief); Free radical substitutions (both aliphatic and aromatic)

Eliminations: E1, E2, E1CB reactions (in detail)Elimination vs Substitution.

Molecular Rearrangement (8)

  • Benzidine, Pinacol, Benzilic acid, Favorskii, Wolff, Hofmann, Cartius, Schmidt, Lossen,
    Beckman, Dienone phenol, Fries (Some idea of migratory aptitude), Demyanov, Baeyer- Villiger, Claisen, Cope and Wagner-Meerwein (only in brief).

Photochemistry: (4)

  • Brief introduction, Norrish type I and type II cleavage, photoreduction, Patterno-Buchi reaction, cis- trans isomerisation, Chemistry of vision.

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  • March, J., Advanced Organic Chemistry, 4th ed, 1999.

  • Nasipuri, D., Stereochemistry of Organic Compounds, 2nd ed., 1995.

  • Solomons, T. W. G., Organic Chemistry 6th ed, 1996.

  • Sykes, Peter, A guide book to Mechanism in Organic Chemistry.

  • R. Bruckner, Advanced Organic Chemistry, 2002

  • R. Bruckner, Organic Mechanisms, 2010

  • M. B. Smith, Organic Synthesis, 3rd Ed. 2010

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