Enzyme- reactions mechanism and kinetics


3-0-0 (9)


Courses with significant overlap with this course:

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CHM 481

Course Contents:

Enzyme kinetics of single and multiple substrate systems including Enzyme assays and inhibition
(15 lectures)

Cooperativity and multienzyme systems (4 lectures)

Enzyme structure and identification of active site residues labelin, chemical modification and mutagenesis
(6 lectures)

Enzyme Mechanisms – Methods of study and mechanisms of some enzymes like
Serine proteases, polymerases, ribonucleases, lysozyme and ribonucleotide reductases (radical enzyme)
(15 lectures)

Mechanism based enzyme inhibition and drugs –5-fluorouracil for thymidylate synthase
(2 lectures)



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  1. Allan Ferhst, Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding.

  2. N. C. Price and E. Stevens,  Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins.

  3. I. H. Segel, Biochemical calculations, How to Solve Mathematical Problems in General Biochemistry, 2nd Edition.



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