Anand Singh

PhD (Vanderbilt University)

Assistant Professor, Department of Chemistry

Specialization

 

Education

  • PhD (2009) Vanderbilt University, USA.
  • M. Sc. (2004) Indian Institute of Technology Bombay.

Website(s)

CV

Our recently established research group at IITK has research interests broadly encompassing the areas of enantioselective  catalysis, development of new reactions, and medicinal chemistry.

The unifying theme of our research is the development of new and efficient chemical transformations in order to create novel small molecule organics for potential applications in the fields of medicine, material science, and agrochemicals. One of our programs focuses on the development of novel fluorination reactions. Owing to the important applications of fluorinated compounds as drugs, diagnostic tools (PET imaging), and as agrochemicals, the synthesis of such molecules is of contemporary interest, and our lab is exploring the synthesis of novel fluorinated small molecules by developing fluorination strategies that employ fluoride anion as the source of fluorine. In addition to expanding the fluorinated chemical space, this strategy will lead to a more economical approach toward fluorinated compounds as opposed to the vast majority of current methods that employ electrophilic fluorination reagents.

A second area of research in our laboratory is photoredox catalysis wherein we aim to develop visible-light mediated reactions. Visible light represents an abundant, inexpensive, and clean source of energy and through its synergistic use with a suitable catalyst, it has been possible to activate certain types of organic molecules toward interesting, novel, and useful reactions. We are investigating a variety of olefin functionalization and cyclization reactions that will result in novel scaffolds that are valuable synthetic intermediates and also represent novel chemical spaces relevant to drug discovery and chemical biology.


 

  • A Diastereo- and Enantioselective Synthesis of α-Substituted syn-α,β-Diamino Acids,
    J. Am. Chem. Soc., 130, 5866 (2008). (Highlighted in Syn. facts 2008, 7, 0757).

  • Chiral Proton Catalysis: Enantioselective Brønsted Acid Catalyzed Additions of Nitroacetic Derivatives as Glycine Equivalents,
    J. Am. Chem. Soc., 129, 3466 (2007).

  • A [3+2] Cycloaddition Route to 3-Hydroxy-3-Alkyl Oxindoles: An Approach to Pyrrolidinoindoline Alkaloids,
    Org. Lett., 13, 2118 (2011).

  • Efficient Assembly of 3-Substituted Oxindole-based Isoxazolines Leading
    to the Synthesis of (±)-Flustraminol-B and related Natural Product Building Blocks,
    Tetrahedron Lett., 53, 4889 (2012).

  • Synthesis of OxindolylPyrazolines
    and 3-Amino Oxindole Building Blocks via a Nitrile Imine [3+2] Cycloaddition Strategy,
    Org. Lett., 14, 5266 (2012).

  • Postdoctoral Associate, Sanford-Burnham Medical Research Institute at Lake Nona, Orlando-FL, U.S.A., 2009-2012; IIT Kanpur, 2013-

  • Mitchum E. Warren Fellowship

  • Research and University Graduate School Fellowship

Office

FB436 ,
Department of Chemistry
IIT Kanpur,
Kanpur 208016

Office Phone: 0512-259-6788 (O)

Email: anands[AT]iitk.ac.in

   
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