The Mehta Family Centre for Engineering in Medicine

Indian Institute of Technology Kanpur

In conversation with Prof. R. Sankararamakrishnan recipient of the “Distinguished Teacher Award” IIT Kanpur, 2023
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Prof. Nitin Gupta and team in a pioneering study display how individual chemical odorants are perceived and processed by the neuronal circuitries in the mosquito brain. Their results provides a unifying foundation to understand the neural basis of olfaction.

A study by Prof. Sandeep Verma and group demonstrating the fabrication and use of highly sensitive PAN nanofiber and Silver nanoparticle-based SERS sensor for detection of β-Amyloid Peptides for Alzheimer's disease. The study offers potential to develop breakthrough platforms for ultra sensitive and selective detection of multiple biomarkers.

Recurrent joint bleeding in hemophilic patients can lead to a painful condition of hemophilic arthropathy. Prof. Jayandharan Rao & team have identified, using a hemophilia mice model, key molecules that could be responsible for rapid degeneration of joint cartilage. The study opens up possibilities of using these as potential therapeutic targets to check the disease progression.

Multi-Drug-Resistance (MDR) poses a serious public health concern; Prof. Sandeep Verma and team in a collaborative effort have come up with a rationally designed cationic peptide conjugate that displays effective antibacterial activity against clinical MDR S. aureus. The study paves way to develop inhibitors for severe staphylococcal infections.

Prof Jonaki Sen talks about her recent study on forebrain development in chick embryo. Prof. Sen discusses how her team identified novel downstream mediator of retinoic acid signaling required for invagination of forebrain roof plate, and how this study could help better understand certain defects leading to cerebral malformation in humans.

GPCRs represent one of the largest family of cell-surface receptors regulating a plethora of cellular events and biological processes. In a collaborative study, Prof. Arun Shukla & Prof. Stephan Grzesiek, their teams demonstrate how multi-site phosphorylation controls interaction of GPCR or Chemokine Receptor with Arrestin. The study paves for better understanding of the diversity of GPCR signaling and developing potential intervention strategies.

How diverse phosphorylation patterns in GPCRs influence recruitment, activation, & functional outcomes of its interacting partners is key to a comprehensive understanding of GPCR Biology. Prof. Arun Shukla & team, in a seminal study, using Cryo-EM have identified a novel motif in GPCRs that is critical for interaction and activation of its key molecular partner, the beta-Arrestins. The study paves way for design of novel intervention strategies targeting GPCR signalings.

Stable Recombinant Invasion Plasmid Antigen C (IpaC)-Based Single Dose Nanovaccine for Shigellosis. Baruah N, Halder P, Koley H, Katti DS. Mol Pharm. 2022.

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Amyloid deposition in granuloma of tuberculosis patients: A single-center pilot study. Ghosh S, Kala C, Garg A, Thakur AK. Tuberculosis (Edinb). 2022 Sep;136:102249.

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Development of a Self-Adjuvanting, Cross-Protective, Stable Intranasal Recombinant Vaccine for Shigellosis.

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Designing BH3-mimetic peptide inhibitors for the viral Bcl-2 homologs A179L and BHRF1: Importance of long-range electrostatic interactions.

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Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression.

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Stable Recombinant Invasion Plasmid ANtigen C (IpaC)-Based Single Dose Nanovaccine for Shigellosis

Carboxylated chitosan-mediated improved efficacy of mesoporous silica nanoparticle-based targeted...

Distinct neural activations correlate with maximization of reward magnitude versus frequency


The Bhupat & Jyoti Mehta Family Foundation

MFCEM at the Indian Institute of Technology Kanpur is generously supported by the Mehta Family Foundation.

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