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Namrata Singh
PhD (Indian Institute of Science)
Assistant Professor, Department of Chemistry
Office
FB 437, Faculty Building,
Department of Chemistry
Indian Institute of Technology Kanpur,
Kanpur 208016
Specialization
Chemical Biology, Bioinorganic Chemistry, Nanomaterials for Biomedical Applications
Selected Publications
Singh, G. R. Sherin, G. Mugesh, “Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next-Generation Therapeutics” Angew. Chem. Int. Ed., 2023, 135, e202301232.
Singh, S. K. Naveen Kumar, M. Geethika, G. Mugesh, “Cerium Vanadate Nanozyme with Specific Superoxide Dismutase Activity Regulates Mitochondrial Function and ATP Synthesis in Neuronal Cells” Angew. Chem. Int. Ed., 2021, 60, 3121-3130.
Singh, K. P. Raul, A. Poulose, G. Mugesh, V. Venkatesh, “Highly Stable Pyrimidine Based Luminescent Copper Nanoclusters with Superoxide Dismutase Mimetic and Nitric Oxide Releasing Activity” ACS Appl. Bio Mater., 2020, 3, 7454-7461.
Singh, G. Mugesh, “CeVO4 Nanozymes Catalyze the Reduction of Dioxygen to Water without Releasing Partially Reduced Oxygen Species” Angew. Chem. Int. Ed., 2019, 58, 7797-7801.
T. Prakash†, N. Singh†, V. Venkatesh, “Synthesis of Novel Luminescent Copper Nanoclusters with Substituents Driven Self-assembly and Aggregation Induced Emission (AIE)” Chem. Commun., 2019, 55, 322-325. (†Equal 1st author)
Singh, M. Geethika, S. M. Eswarappa, G. Mugesh, “Manganese-Based Nanozymes: Multienzyme Redox Activity and Effect on the Nitric Oxide Produced by Endothelial Nitric Oxide Synthase” Chem. Eur. J., 2018, 24, 8393-8403.
Singh, M. A. Savanur, S. Srivastava, P. D’Silva, G. Mugesh, “A Redox Modulatory Mn3O4 Nanozyme with Multi-enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model” Angew. Chem. Int. Ed., 2017, 56, 14267-14271.
Awards & Fellowships
Karolinska Institute Research Foundation Grant 2023.
MSCA Vinnova Postdoctoral Fellowship 2022, Swedish Innovation Agency Vinnova.
IUPAC-Solvay International Award for Young Chemists 2020.
Alexander von Humboldt Postdoctoral Fellowship 2020 (Not availed).
ETH Zürich Postdoctoral Fellowship 2020 (Not availed).
Metrohm Young Chemist Award 2019, Metrohm India and IIT-Bombay.
Indian Academy of Sciences, IASc-INSA-NASI Summer Research Fellowship 2011.
Professional Experience
Assistant Professor, IIT Kanpur, Kanpur, India, 2024 onwards
Scientist, CSIR-Central Drug Research Institute, Lucknow, India, 2023-2024
Postdoctoral Fellow, Karolinska Institute, Stockholm, Sweden, 2022-2023
Postdoctoral Fellow, Imperial College London, London, UK, 2020-2022
Research Associate, Indian Institute of Science, Bangalore, India, 2018-2019
Current Research
Our group works at the intersection of material chemistry and biology, with a vision to engineer next-generation nanomaterials for therapeutic and diagnostic applications. We are interested in tackling pressing healthcare challenges, including antimicrobial resistance, resilient infections, and cancer, while also exploring strategies for early disease detection. By integrating rational nanomaterial design with biological insights, we aim to create multifunctional systems that can combat bacterial infections through bioinspired and stimuli-responsive approaches, develop precision nanomedicines capable of modulating the tumor microenvironment and programmed cell-death pathways, and design nanoscale diagnostic platforms for detecting low-abundance biomarkers in complex biological environments. At the same time, we seek to deepen the understanding of how nanomaterials interact with cells and tissues, so as to guide the development of safer and more effective biomedical systems. Through interdisciplinary collaborations and sustained innovation, our long-term goal is to contribute transformative nanotechnologies that advance the future of healthcare.