+91-512-259-7629

head_che@iitk.ac.in

Raghvendra Singh

Associate Professor

Research Interest

  • Stem Cells
  • Stochastic Processes
  • Systems Biology
  • Stem Cells and Statistical Mechanics
  • Cancer Stem Cells
  • Signal Transduction

Education

  • B.E., University of Roorkee, 1998
  • Ph.D., State University of New York at Buffalo, 2008

Research Overview

Stem cells are at the core of the normal developmental processes and in many pathological conditions. We study both embryonic and adult stem cell fate decisions using systems biology approach in the context of both normal homeostasis and in human diseases. Further, stem cell fate decisions are stochastic in nature. We apply statistical mechanics to study the lineage and differentiation of these cells.

Publications

  • Alok Jaiswal, Raghvendra Singh, CtBP: A global regulator of balancing acts and homeostases, BBA-Reviews on Cancer (Elsevier), 1878, 3 (2023).
  • Alok Jaiswal, Raghvendra Singh, Loss of Epidermal Homeostasis Underlies the Development of Squamous Cell Carcinoma, Stem Cell Reviews and Reports, (2022).
  • Alok Jaiswal, Raghvendra Singh, Homeostases of epidermis and hair follicle, and development of basal cell carcinoma, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1877, 188795 (2022).
  • Raghvendra Singh, Basal cells in the epidermis and epidermal differentiation, Stem cell Reviews and Reports, 18, 1883 (2022).
  • Raghav Saxena, V B K Sai Phani Kumar Avanigadda, Raghvendra Singh, Vishal Agarwal, Ab initio dynamics of gas-phase and aqueous-phase hydrolysis of adenosine triphosphate, International Journal of Quantum Chemistry, 121, (2021).
  • Satyam Gupta, Neeraj Koshta, Raghvendra Singh, Goutam Deo, Flue Gas Treatment via Dry Reforming of Methane, Catalysis for Clean Energy and Environmental Sustainability, 319, (2021).
  • Singh R., Aberration in NFkB-IkB binding may cause two states of NFkB activity, CURRENT SCIENCE, 113(11), (2017).
  • Singh R., Central role of PI3K - SYK interaction in fibrinogen-induced lamellipodia and filopodia formation in platelets, FEBS Open Bio, 1285, (2016).
  • Singh R., Model Predicts That MKP1 and TAB1 Regulate p38α Nuclear Pulse and Its Basal Activity Through Positive and Negative Feedback Loops in Repsonse to IL-1, PLoS ONE, 11(6), (2016).
  • Singh R., Signal Oscillation Is Another Reason for Variability in Microarray-Based Gene Expression Quantification, PLoS ONE, 8(1), (2013).
  • Gupta S, Singh R., Analysis of the Virus Dynamics Model Reveals That Early Treatment of HCV Infection May Lead to the Sustained Virological Response, PLoS ONE, 7(7), (2012).
  • Singh R., Nitsche J.M. and Andreadis S.T., An Integrated Reaction-Transport Model for DNA Surface Hybridization: Implications for DNA Micro arrays, Annals of Biomedical Engineering, 37(1), (2009).
  • Singh R., Lei P., and Andreadis S. T., PKC-delta binds to E-cadherin and mediates EGF induced cell-scattering, Experimental cell research, 315(17), (2009).
  • Singh R., and Andreadis S. T., EGF receptor activation decreases retroviral gene transfer through protein kinase C-delta, Molecular Therapy, 15(2), (2007).