Title of Talk

Cyanations with benzyl cyanide — An environmentally benign and operational safety cyanation reagent

 

Abstract

Benzyl cyanide can be used as a feasible cyanation reagent with environmentally benign and operational safety. Reactions were realized either by palladium-catalyzed C-CN bond activation of benzyl cyanide or from the decomposition of a-cyanohydrin which was in situ generated through the copper-catalyzed benzilic C-H oxidation of benzyl cyanide. Various substrates, for instance, aryl halides, arenes with or without directing group, and aryl boronic acids or esters, were suitable and furnished the corresponding cyanated products in moderate to good yields.

 

 

 

 

 

 

Ping Lu, Professor

 

Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China

e-mail: pinglu@zju.edu.cn

 

Profile. Ping Lu was born in Zhejiang, China in 1964. She received B.S. (1984), and Ph.D. (1990) degrees from Hangzhou University, currently called Zhejiang University. Since 1990, she became a faculty member and was promoted to be a full professor in 1998 at the same university. Since 1995, she has worked for three years as a visiting scholar with Prof. W. P. Weber in University of Southern California. Her research interests include the synthetic methodology, the fluorescent structure-property relationship, and the fluorescent materials and chemosensors.

 

Selected Publications

1. Wang, C., Zhang, L. P, Lu, P., Wang, Y. G., Org. Lett. 2013, 15, 2982

2. Li, JC., Hu, G. F., Wang, N. N., Hu, T., Wen, Q. D., Lu, P.; Wang, Y. G. J. Org. Chem. 2013, 78, 3001

3. Hu, B. B., Chen, X. P., Wang Y. F., Lu, P.; Wang, Y. G., Chem. Asian J. 2013, 8, 1144

4. Wen, Q. D., Jin, J. S, Hu, B. B., Lu, P., Wang, Y. G. RSC Advances, 2012, 2, 6167

5. Jin, J. S., Wen, Q. D., Lu, P., Wang, Y. G. Chem. Commun., 2012, 48, 9933