Process for Synthesis of Nanocrystalline Hydroxyapatite

Patent Status: 

Patent Filed

Indian Patent Applicaton No: 


Patent Category: 


An efficient, inexpensive, low temperature and scalable process for synthesis of nanocrystalline hydroxyapatite through mechano-chemical root.

Key Features: 

  • The reaction milling process is carried out in single step.
  • The synthesis of nanocrystalline hydroxyapatite uses calcium hydroxide as calcium source powder and phosphorous pentoxide as phosphorous source powder.
  • No external heat is applied during the process of reaction milling.
  • The reaction milling time for the synthesis of nanocrystalline hydroxyapatite is 1 hour.
  • The stoichiometric ratio of calcium hydroxide powder and phosphorous pentoxide powder is 1.74: 1
  • Yield of hydroxyapatite is 99 %.,no post milling treatment is necessary, average particle size is 50 nm or less can be obtained and phase control is achieved with relative ease.


  • Nanocrystalline hydroxyapatite can be used as a bone substitute material.
  • It can be used for drug delivery system.
  • It can be used as a medicine for calcium source.

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