Process for Preparation of Chiral Y-Lactams

Patent Status: 

Patent Filed

Indian Patent Applicaton No: 

1870/DEL/2010

Department: 

Patent Category: 

Overview: 

Process for synthesis of biologically important Y-lactams.

Key Features: 

  • Present patent describes an efficient process for synthesis of chiral Y-lactams from reaction of aziridines and active methylene carbon nucleophiles.
  • The reaction utilizes starting materials which are either commercially available or can be easily synthesized in easy no. of steps.
  • This patent describes a process where enantiomerically and diastereomerically pure Y-lactams can be synthesised in a single step.
  • Reaction avoids use of any hazardous or toxic material.

Applications: 

  • Several drugs based on chiral GABA scaffold (e.g. Pregabalin (Lyrica).
  • Functional core of various drugs.
  • This method can be used for synthesis of a large no. of drug like molecules having Y-lactam or GABA core.

 

 

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