A Drug Screening Process and a Drug Formulation for Huntington’s disease

Patent Status: 

Patent Filed

Indian Patent Applicaton No: 

1182/DEL/2015

Patent Category: 

Overview: 

Prevention of adsorption of molecules in protein aggregation inhibitors discovery.

Key Features: 

  • Bovine serum albumin (BSA) when present in aqueous solution of aggregation assay prevents surface adsorption of a hydrophobic molecule (CLC), thus makes it available to act on HDeX1 aggregating peptide during suspension assay.

  • Use of BSA in aqueous solution of aggregation assay to make complex of BSA-CLC to prevent surface adsorption of hydrophobic molecule.

  • Enhancement of aggregation inhibition activity of HDex1 by BSA-CLC.

Applications: 

  • Time Reduction in drug discovery

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