Disaggregation and Solubilization of Synthetic Polypeptides

Patent Status: 

Patent Filed

Indian Patent Applicaton No: 


Patent Category: 


Solubilizing polypeptides to soluble monomers

TEM show long fibrillar structures of similar morphology with TFA and TFA/HFIP

Key Features: 

  • Method for disaggregating and solubilizing polypeptides that renders a process wherein the insoluble aggregates are converted to soluble monomers.
  • Modification of the existing method that uses TFA/HFIP wherein HFIP is replaced with additional TFA
  • It reduces the cost as well as minimized the number of process steps in disaggregating and solubilizing the synthetic polyglutamine peptides.


  • Company or research and development center that is working with proteins or peptides can use this method for solubilization

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