UG Course
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The students of BSBE will take courses common with all other branches of science and engineering in the first year. During their second year, they will take foundation and elective courses in basic biology and bioengineering topics, besides developing their interest and excitement in biological experimentations and discoveries. Concepts in biology will be sharply focused on to provide a holistic view and to facilitate integration of these with the fundamental principles of physics, chemistry, mathematics and engineering.The final two years of the program will see the development of .professional competence of the students on a broad spectrum of topics.
Major emphasis during the final semesters will be on research and development along with the development of entrepreneurial skills. Students would also compete for ‘Joy Gill Endowment” scholarship for R&D intership in Bio-pharma and Biotech industries besides participating in Bio-business plan competitions.
BSE 100 INTRODUCTION TO BIOLOGICAL SCIENCES AND BIOENGINEERING, 1-0-0-0-0
Biology in the 21st Century: The brave new world in the post genome era. Past,present and
future of our society, industry
and life style: impact of discoveries
and technological innovations in biology.
Challenges and excitement of research in
biology and bioengineering. Bioengineering
as an emerging science at the intersection
of biology, engineering, physics
and chemistry. Career opportunities in
biotechnology, biomedical engineering,
pharmaceutical industry, agro-biotechnology
and in the diverse areas of basic
science and medical research. Emerging
trends of collaboration between industry
and academia for development of entrepreneurship
in biotechnology. Lab tours.
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BSE 211 CELLULAR AND ORGANISMAL BIOLOGY, 3-0-0-0-4
Single cell Biology: Chemical Foundation
for Cells, Carbon Compounds in Cells, Cell
Structure and Function. Energetic at the
cellular level- Ground Rules of Metabolism,
How Cells Acquire Energy, How
Cells release stored energy. Multicellular
biology: Cell Division and Mitosis, Meiosis,
Principles of Cell structure and function
- Tissue, Organs and Homeostasis, Integration
and Control: Nervous Systems,
Sensory Reception, Endocrine Control,
Protection, Support, and Movement, Circulation,
Immunity, Respiration, Digestion
and Human Nutrition, Reproduction and
Development. Population biology: Ecology
and Behavior, Population ecology,
community interactions, Ecosystems,
Biosphere and behavior.
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BSE 212 INFORMATION PROCESSING IN BIOLOGICAL SYSTEMS, 3-0-0-0-4
Genome as the store house of information,
DNA as the carrier of encoded messages.
Genomic diversity across organisms
as a source of embedded intelligence in nature. Intra-cellular transmission
of genetic messages and their cellular
translation; Cell-cell communication
and feedback; Selective transmission of
genetic messages - regulation of gene
expression; logic of building body plans
developmental translation of encoded
messages. Techniques of DNA manipulation
and engineering.
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BSE 214 EVOLUTION OF BIOLOGICAL MACHINES, 3-0-0-0-4
Living body as an examples of finest
designs for diverse activities, functions
e.g., flying, swimming, reproduction, sensing,
eating, etc. Evolution and natural
selection as the means of optimization of
biological machines at diverse scales:
molecular, cellular, organismal and population.
Principles of micro and macro
evolution. Theories of evolution and
Darwanian selection. Principles of generating
diverse body plan and design in
nature.
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BSE 216 MOLECULES OF LIFE, 3-1-0-0-4
Properties of water, Acids, Bases and
Buffers. First and Second law of thermodynamics;
Free energy as an indicator of
spontaneity; Chemical Equilibria. Amino
Acids of Proteins; Optical Activity. Primary
Structure Determination; Three-Dimensional
Structures of Proteins: Secondary
Structure; Fibrous Proteins;
Globular Proteins; Quaternary Structure.
Polysaccharides; Glyco-proteins. Lipids
and Membranes; Mechanisms of enzyme
action; Substrate Specificity; Coenzymes;
Regulation of Enzymatic Activity: enzyme
kinetics, inhibition; effects of pH. Catalytic
mechanisms, Biosynthesis of amino
acids, lipids and nucleotides.
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BSE 292 BSBE LAB I MOLECULAR BIOLOGY, 0-0-4-0-2
Use of Transgenic organisms in the
study of gene expression methodology
to obtain high affinity antibodies.
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BSE 322 COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 3-0-0-0-4
Biological Databases; Global and local
alignment; pair wise and multiple sequence
alignment; Pattern searching in
DNA & Protein sequences; Alignment
tools, BLAST, FASTA, phylogenetic
prediction, evolutionary tree construction,
gene prediction in prokaryotes,
eukaryotes; Protein structure classification;
Structure prediction from sequence
features, Comparative
genomics.
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BSE 323 PROTEIN STRUCTURE & ENGINEERING, 3-0-0-0-4
Purification of proteins, Chromatography
principles, methods to estimate the concentration
& purity, Principles of Protein
Structure, Methods to determine 3D-Structures.
X-ray crystallography and Nuclear
Magnetic Resonance methods, Biological
Membranes; Membrane Assembly and
Protein Targeting; Signal transduction;
Receptors and hormones; antigen-antibody
relationship. Protein dynamics, Protein
Folding, Dynamics and Structural
Evolution. Elementary ideas of bonding
and structure, stereochemistry; spectroscopic
techniques. Protein Engineering:
Proteins design and engineering, Random,
site directed mutagenesis; Strategies
to alter catalytic efficiency; structure
prediction and modeling proteins; Molecular
graphics in protein engineering;
Dynamics and mechanics; Drug-protein
interactions and Design; applications of
engineered proteins.
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BSE 341 BIOCHEMICAL ENGINEERING, 3-0-0-0-4
Fundamentals of Biochemical engineering:
Stoichiometry and energetics of microbial
metabolism, Transport phenomena,
Enzyme catalyzed reactions and
processes, Bioreactor design and
applications, Sterilization, Instrumentation
and control, Bioseparations and bioprocesses:Downstream processing
characteristics of biological materials,
pretreatment methods; separation of cell
biomass, adsorption, filteration, reverse
osmosis, isoelectroc focusing, affinity
based separation, polishingcrystallization,
drying, case studies;
Process integration Bioprocess
integration for efficient production and
recovery, scale-up consideration,
process monitoring and process
economics; Environmental bioprocesses
Interaction of mixed microbial
population, applications, biological
wastewater treatment, anaerobic,
digesters, bioremediation.
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BSE 352 BIOMATERIALS, 3-0-0-0-4
Introduction to Materials Science: Bulk
and surface properties of materials;
Polymeric materials; synthesis, characterization,
and fabrication methods–
Inert, biodegradable, hydrogels, Natural,
Genetically engineered and Bioactive;
Ceramics and glasses; Metals; Surface
modification techniques. Biocompatibility
of Biomaterials: Protein structure,
interaction of proteins with synthetic
materials ; Characterization of cellmaterial
interactions; inflammatory
responses; acute inflammation, chronic
inflammation, foreign body response,
assessment of material performance
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BSE 354 INTRODUCTION TO TISSUE ENGINEERING, 3-0-0-0-4
What is tissue engineering? Scope and
objective of tissue engineering; Principles
of tissue engineering; Essential
components of tissue engineering;
Materials Science/Engineering aspects
(degradable materials); Design and
characterization of scaffolds (porosity,
mechanical strength and 3-D architecture);
Cell Biology aspects (choice
of cell type, progenitor cells and cell
differentiations); Molecular biology aspects
(cell signaling molecules-growth
factors, cell attachment-integrins); Drug
delivery in tissue engineering; Commercial developments of tissue engineering;
Future of tissue engineering
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BSE 391 BSBE LAB II BIOCHEMISTRY AND BIOCHEMICAL ENGINEERING, 0-0-9-0-5
Estimation of proteins by UV, Bradford
and Lowry methods. SDS-PAGE separation
of proteins Enzyme Kinetics- Salivary
amylase- different pH buffers and
temperature Chromatography- Ion exchange/
HPLC/ GC/affinity Determination
of molecular weights by Gel chromatography.
Estimation of sugars/ blood cholesterol
Respiration of mitochondria and
oxidative phosphorylation. Bioreactors
and bioprocess engineering – use computer
simulation to explore mass transfer
phenomena and cell growth kinetics.
Bioseparation using smart polymers.
Yeast antibody library screening- use
state-of-art combinatorial library screening
methodology to obtain high affinity
antibodies.
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BSE 392 BSBE LAB III – STRUCTURAL BIOLOGY & BIOINFORMATICS, 0-0-4-0-2
De novo protein design and artificial proteins:
approaches used in designing and
constructing novel proteins. Structure
based drug design: Virtual screening techniques,
designing pharmacaphore models,
scoring function and their relevance
in downsizing hit lists. Determination of
Protein structure by X-ray crystallography:
protein purification, current methods
in protein crystallization. Evaluating
the quality of crystals, crystal freezing at
low temperature for data collection. A
demonstration session on X-ray diffraction
data collection and processing at
CDRI, Lucknow.
Bioinformatics Training with Insight
Molecular modeling package, Exercises
involving homology modeling of protein
structures, Pairwise and multiple sequence alignments using tools such as
BLAST, FASTA, CLUSTAL and from GCG
suite of programs
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BSE 441 BIOMECHANICS, 3-0-0-0-4
Introduction to biomechanics. Bio-sensors,
actuators and control. Analysis
of bio-system as a flexible structure.
Aerodynamics, hydro-dynamics and
locomotion. Bio-statics and Bio-dynamics
I – Mechanics of motion, friction,
fracture. Biodynamics II – Work, energy
and power. Bio-dynamics III. Fluid Mechanics
- Examples of Archimedes principles,
Pascal Law, Bernoulli’s theory
and the living world, Viscosity and turbulence,
Human circulatory system.
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BSE 491 BSBE LAB IV- BIOMECHANICS AND BIOMATERIALS, 0-0-4-0-2
Biomechanics: Human body motion
analysis. Control of artificial arms/legs
using biological principles. Rehabilitation
applications of biomechanics. Biosensors
and MEMS: Development of
sensors for measuring pressure,
temperature, force at the fingertips and
soles of the feet. Polymer spinners and
micro lithography. Testing of synthetic
materials
Biomaterials: Biodegradable polymerssynthesis,
fabrication test their characteristic,
computational simulation of biomaterial
for their mechanical strength,
tissue compatibility and prosthetic devices.
Modeling natural material like wood,
bamboo, fish-bone, plant stem etc.. Modeling
human tissue and tissue biomaterial
interactions.
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