Academic Background:

Dr.Jamuna R. Subramaniam was a Senior Research Associate in Astra Research Center India, Bangalore before her predoctoral studies. Her graduate studies were in Georgetown University (USA). After her postdoctoral training in the School of Medicine, Johns Hopkins University (USA) she joined the BSBE department in October, 2002.

Research Interests:

Mechanism of lifespan extension and its connection with protection against neurodegenerative diseases (NDs).
Therapeutic strategies for NDs.
Generation and characterization of neuronal and non-neuronal cells from human umbilical cord.
Developed drug screening system for their effect on Cytochrome P450s

Selected Publications:

Arya, U., Dwivedi,H.,Subramaniam,J.R., Reserpine ameliorates Abeta toxicity in the Alzheimer's disease model in C. elegans. Exp Gerontol 2009. 44(6-7): p. 462-466.
Vijayalakshmi K, Alladi PA, Sathyaprabha TN, Subramaniam JR, Nalini A, Raju,TR (2009) Cerebrospinal Fluid from sporadic Amyotrophic Lateral Sclerosis patients induces degeneration of a cultured motor neuron cell line. Brain Research 31;1263:122-33.
Srivastava D, Arya U, Soundar Rajan T, Dwivedi H, Kumar S and Subramaniam JR (2008) Reserpine can confer lifespan extension in C.elegans. Biogerontology 9(5):309-16.
Chakrapani, PS, Kumar S and Subramaniam JR (2008) Development and evaluation of an in vivo assay in C.elegans for screening of compounds for their effect on cytochrome P450 expression. J. of Biosciences 33(2) 269-277.
Teixidor GT, Gorkin RA 3rd, Tripathi PP, Bisht GS, Kulkarni M, Maiti TK, Battacharyya TK, Subramaniam JR, Sharma A, Park BY, Madou M (2008) Carbon microelectro-mechanical systems as a substratum for cell growth. Biomed Mater. 3(3):034116.
Liu J, Lillo C, Jonsson PA, Velde CV, Ward CM, Miller TM, Subramaniam JR, Rothstein JD, Marklund S, Andersen PM, Brannstrom T, Gredal O, Wong PC, Williams DS, Cleveland DW.(2004) Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron 43(1), 5-17.
Carroll MC, Girouard JB, Ulloa JL, Subramaniam JR, Wong PC, Valentine JS, Culotta VC.(2004) Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone. Proc Natl Acad Sci U S A. 101(16), 5964-9.
Martin LJ, Price AC, McClendon KB, Al-Abdulla NA, Subramaniam JR, Wong PC,
Liu Z.(2003) Early events of target deprivation/axotomy-induced neuronal apoptosis in vivo: oxidative stress, DNA damage, p53 phosphorylation and subcellular redistribution of death proteins. J Neurochem. 85(1):234-47.
**Subramaniam, JR, Lyons, WE, Liu, JJ, Bartinikas, TB, Rothstein, J., Price, DL, Cleveland, DW, Gitlin, JD and Wong, PC.(2002) Mutant SOD1 causes motor neuron disease independent of CCS-mediated copper loading. Nature Neuroscience 5(4):301-7 (2002).
** - an important contribution to the field. This paper appeared with News and Views in Nature Neuroscience 5, 287-288 (2002) and a Highlight in Nature Reviews Neuroscience 3, 258 (2002).
Wong, PC, Price, DL and Subramaniam, JR “Experimental Genetics as a tool for understanding pathogenesis in ALS. In “Pathogenesis of neurodegenerative disorders” Edited by Mattson, MP. Humana Press Inc (2001).
Subramaniam, JR, Corsi, L, Vicini, S, Whiting, PJ and Neale, JH (2001) Ribozyme-mediated reduction of the GABAA receptor ?1 subunit. Brain Res Mol Brain Res 92(1-2): 149-56.
Wong PC, Waggoner D, Subramaniam JR, Tessarollo L, Bartnikas TB, Culotta VC, Price DL, Rothstein J, Gitlin JD (2000) Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. Proc Natl Acad Sci USA 97(6): 2886-91.